10įurthermore, diazepam is a useful adjunct for the relief of skeletal muscle spasm due to reflex spasm to local pathologies, such as inflammation of the muscle and joints or secondary to trauma spasticity caused by upper motor neuron disorders, such as cerebral palsy and paraplegia athetosis and the rare "stiff man syndrome". Moreover, in acute alcoholic withdrawal, diazepam may be useful in the symptomatic relief of acute agitation, tremor, and impending acute delirium tremens. In general, diazepam is useful in the symptomatic management of mild to moderate degrees of anxiety in conditions dominated by tension, excitation, agitation, fear, or aggressiveness such as may occur in psychoneurosis, anxiety reactions due to stress conditions, and anxiety states with somatic expression. Type Small Molecule Groups Approved, Illicit, Investigational, Vet approved Structure This current development is subsequently an important addition to the rescue therapy tool chest for patients with epilepsy 7. Combining diazepam, a proven effective therapy for acute repetitive seizures, with an auto-injector designed for subcutaneous administration that is quickly and easily administered offers the potential for complete, consistent drug absorption and rapid onset of effect 7. ![]() Given diazepam's storied history as a commonly used and effective medication for a variety of indications, contemporary advancements in the formulation and administration of the agent include the development and US FDA approval of an auto-injectable formulation for the rapid treatment of uncontrolled seizures in 2015-2016 7. (From Martindale, The Extra Pharmacopoeia, 30th ed, p589) It is used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome. ![]() Its actions are mediated by enhancement of gamma-aminobutyric acid activity. Diastat, Valium, Valtoco 5 Mg Dose Kit Generic Name Diazepam DrugBank Accession Number DB00829 BackgroundĪ benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action.
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